Video 2. Large lipoplex-vesicle transfection.

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Fusion of the large lipoplex from inside the endosomal vesicle. The headgroups of the endosomal and lipoplex lipids are subsequently blue and orange. The endosomal lipids have dark grey tails and the lipoplex lipids have light grey tails. Yellow and pink are used for subsequently the bases and backbone of the dsDNA. No bias was applied during this simulation, though opening of the first channel occurred by a biasing potential as described in the methods section.