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. Author manuscript; available in PMC: 2020 Sep 25.
Published in final edited form as: Nature. 2020 Mar 25;580(7803):413–417. doi: 10.1038/s41586-020-2136-9

Figure 4. Proposed mechanism of IrtAB-mediated mycobactin uptake.

Figure 4

IrtAB imports both Fe-MBT and Fe-cMBT across the inner membrane. For Fe-cMBT, an alternative import mechanism exists. After import, Fe-MBT remains anchored to the membrane and is thereby ideally positioned for reduction by the SID. The SID is essential for iron utilization via Fe-MBT, but not via Fe-cMBT. Iron-bound mycobactins are shown in red, desferrated mycobactins in white.