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. Author manuscript; available in PMC: 2020 Sep 25.
Published in final edited form as: Nature. 2020 Mar 25;580(7803):413–417. doi: 10.1038/s41586-020-2136-9

Extended Data Figure 1. Sequence identity of IrtAB homologues and crystal structure of IrtAB determined with the help of a sybody.

Extended Data Figure 1

a, Sequence identity matrix of full-length IrtAB from M. thermoresistibile (Mth), M. smegmatis (Msm) and M. tuberculosis (Mtb). b, IrtABΔSID of M. thermoresistibile (lacking the SID and the linker between SID and TMD of IrtA) was crystallized with the help of a synthetic nanobody (sybody). IrtA is colored in turquoise, IrtB in purple and the sybody in grey with CDRs 1, 2 and 3 colored in yellow, orange and red, respectively.