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. Author manuscript; available in PMC: 2020 Aug 5.
Published in final edited form as: Nature. 2020 Feb 5;578(7796):627–630. doi: 10.1038/s41586-020-1995-4

Figure 1. The structure of human TG by cryo-EM.

Figure 1

a) Domain assignment of human thyroglobulin. Five regions (NTD, Core, Flap, Arm and CTD) contain domains of type-1 to type-3 TG repeats, as well as the choline esterase-like domain (ChEL), labelled as A to V. b) Structural gallery of all resolved TG domains. c) TG cryo-EM map where individual subunits are coloured blue and grey. The NTD crosses the major C2 interface. d) Ribbon diagram of panel c), coloured as in panel a). e) Schematic representation of TG structure in the same colour scheme as in a) and d).