Skip to main content
. Author manuscript; available in PMC: 2021 May 10.
Published in final edited form as: J Control Release. 2020 Jan 29;321:272–284. doi: 10.1016/j.jconrel.2020.01.051

FIG. 6.

FIG. 6.

Heat map of the screening results of therapy-induced cytokine expression changes in tumors, lymph nodes and serum. Cytokine expressions were assessed in tumors, tumor-associated lymph nodes (tumor lymph nodes) and in serum of tumor-bearing mice (tumor serum) prior to treatment (control) and 0.5, 6, and 24 h after treatment with UTMD-mediated delivery of miR-122-/anti-miR-21-loaded NPs. Decrease in cytokine expression is indicated in blue and increase is shown in red. As a reference, the cytokine expression in control tissues (without treatment) was set to 100% (shown in grey). The currency sign (¤) indicates that the cytokine expression was higher than the depicted maximum of 533% (IFN-γ at 1918%, TNF-α at 921%, RANTES at 1112%). For statistical analysis, all treated samples were compared to the untreated control.