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. 2019 Jun 5;27(3):147–167. doi: 10.1038/s41417-019-0109-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — PROM1 expression analysis in different cancer types (Oncomine and TCGA databases). a The box plot comparing PROM1 expression in normal (left plot) and cancer tissues (right plot) were derived from the Oncomine database. The fold change of PROM1 in various cancer types was determined from the analyses shown in Supplementary Table 1 (i). Analysis of SBC relative to normal bladder (ii), GBM relative to normal brain (iii), MBC relative to normal breast (iv), BE relative to normal esophagus (v), CCSK relative to normal kidney (vi), PBALL relative to PBMC (vii), cirrhosis relative to normal liver (viii), TEC relative to normal testis (ix), OMA relative to normal ovary (x), BMSN relative to normal skin (xi) and GST relative to normal stomach (xii). The threshold was designed with the following parameters; p-value = 0.01, fold change = 2, and gene rank = 10%. b PROM1 expression in The Cancer Genome Atlas (TCGA) database. Box plots showing PROM1 mRNA expression in various tumor (T) and corresponding normal (N) tissues, using TCGA data from GEPIA (i-x). The threshold was designed with the following parameters: p-value = 0.01, fold change = 2. SBC superficial bladder cancer, MBC mucinous breast carcinoma, BE Barrett’s esophagus, EA esophageal adenocarcinoma, CCSK clear cell sarcoma of the kidney, CRCC chromophobe renal cell carcinoma, PBMC peripheral blood mononuclear cell, PBALL pro-B acute lymphoblastic leukemia, TEC testicular embryonal carcinoma, OMA ovarian mucinous adenocarcinoma, OCCA ovarian clear cell adenocarcinoma, BMSN benign melanocytic skin nevus, GST gastrointestinal stromal tumor, BLCA bladder urothelial carcinoma, BRCA invasive breast carcinoma, CHOL cholangiocarcinoma, COAD colon adenocarcinoma, ESCA esophageal carcinoma, GBM glioblastoma multiforme, HNSC head and neck squamous cell carcinoma, KICH kidney chromophobe, KIRC kidney renal clear cell carcinoma, LAML acute myeloid leukemia, OV ovarian serous cystadenocarcinoma, PAAD pancreatic adenocarcinoma, READ rectum adenocarcinoma, STAD stomach adenocarcinoma, TGCT testicular germ cell tumor, THCA thyroid carcinoma, UCEC uterine corpus endometrial carcinoma, UCS uterine carcinosarcoma