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. 2019 Jun 5;27(3):147–167. doi: 10.1038/s41417-019-0109-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Correlation of PROM1 and PROM2 expression with prognosis of various cancers (PrognoScan, R2: Kaplan Meier Scanner, Kaplan–Meier plotter, SurvExpress, and OncoLnc). a Survival curves comparing patients with high (red) and low (blue) PROM1 expression were plotted using breast (i and ii), brain (iii), prostate (iv), skin (v), soft tissue (vi), and lung (vii) cancer data from PrognoScan; esophageal cancer (viii) and sarcoma (ix) data from R2: Kaplan Meier Scanner; gastric (x) and ovarian (xi) cancer data from Kaplan-Meier Plotter; and liver cancer (xii) data from SurvExpress. Cox p-value threshold < 0.05. b Survival curves comparing patients with high (red) and low (blue) PROM2 expression were plotted using breast (i and ii), lung (iii), eye (iv), and blood (v) cancer data from PrognoScan; colon cancer (vi), esophageal cancer (vii), lymphoma (viii), and sarcoma (ix) data from R2: Kaplan Meier Scanner; and ovarian cancer (x) data from Kaplan-Meier plotter. Cox p-value threshold < 0.05. c Co-expression of PROM1 and PROM2 with respect to the cancer patient prognosis. Multivariate survival curves comparing the prognosis of patients with high/high (red), high/low (orange), low/high (green), and low/low (blue) expression co-expression patterns of PROM1/PROM2 in KIRC (i), KIRP (ii), and SKCM (iii). Clinical outcome data were retrieved from TCGA using OncoLnc. p < 0.05 represents statistical significance. Abbreviations: KIRC - kidney renal clear cell carcinoma; KIRP - kidney renal papillary cell carcinoma; SKCM - skin cutaneous melanoma