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. 2020 Apr 20;11:1857. doi: 10.1038/s41467-020-15730-x

Fig. 5. Cancer metastasis inhibition by HSN-mediated NIR-II photothermal ferrotherapy.

Fig. 5

a, b Schematic illustration of treatment schedule of monotherapies and photothermal ferrotherapy. H&E images of lung (c) and liver (e) metastasis of living mice after various treatments. Metastatic area was indicated by dotted lines. d Number of metastasis nodules per lung in mice after various treatments. f Area of metastatic lesions in liver per mice after various treatments. P-values were calculated by Student’s two-sided t-test. *P < 0.05, **P < 0.01, ***P < 0.001 (n = 3). g Mechanistic study and h illustration of molecular mechanism of metastasis inhibition by HSN-mediated NIR-II photothermal ferrotherapy. Quantification of expression levels of HGF, MTA2, and VCAM-1 in tumor tissues (at 9 mm, Supplementary Fig. 16) in living mice. T.I. tumor interstitium. Error bars indicated standard deviations of three independent measurements.