Table 5.
HLA-DRB1/DRB1 genotypes distribution in individuals with type 1 diabetes and without T1D.
| Genotypes | T1D Individuals with T1D N (%) | Individuals without T1D N (%) | OR | CI | p value |
|---|---|---|---|---|---|
| DRB1*01/DRB1*XX | 95 (9.32%) | 1862 (36.40%) | 0.18 | 0.14–0.22 | 0.00000 |
| DRB1*03/DRB1*01 | 40 (3.93%) | 99 (1.94%) | 2.07 | 1.42–3.01 | 0.00010 |
| DRB1*03/DRB1*03 | 100 (9.81%) | 52 (1.02%) | 10.6 | 7.52–14.92 | 0.00000 |
| DRB1*03/DRB1*04 | 240 (23.55%) | 127 (2.48%) | 12.1 | 9.64–15.20 | 0.00000 |
| DRB1*03/DRB1*09 | 28 (2.75%) | 16 (0.31%) | 9.01 | 4.85–16.71 | 0.00000 |
| DRB1*03/DRB1*XX | 117 (11.48%) | 668 (13.06%) | 0.86 | 0.70–1.07 | 0.16924 |
| DRB1*04/DRB1*01 | 47 (4.61%) | 128 (2.50%) | 1.88 | 1.34–2.65 | 0.00022 |
| DRB1*04/DRB1*04 | 60 (5.89%) | 82 (1.60%) | 3.84 | 2.73–5.40 | 0.00000 |
| DRB1*04/DRB1*09 | 13 (1.28%) | 21 (0.41%) | 3.13 | 1.56–6.28 | 0.00068 |
| DRB1*04/DRB1*XX | 191 (18.74%) | 843 (16.48%) | 1.17 | 0.98–1.39 | 0.07762 |
| DRB1*09/DRB1*09 | 2 (0.20%) | 0 (0.00%) | |||
| DRB1*09/DRB1*XX | 25 (2.45%) | 121 (2.37%) | 1.04 | 0.67–1.61 | 0.86596 |
| DRB1*XX/DRB1*XX | 61 (5.99%) | 1109 (21.68%) | 0.23 | 0.18–0.30 | 0.00000 |
T1D = type 1 diabetes mellitus; n = number of individuals; OR = odds ratio; CI = confidence interval; p required for significance after Bonferroni correction 0.004. DRB1*XX = any haplotype other than DRB1*03, DRB1*04 or DRB1*09.