Table 6.
Distribution of the HLA-DRB1~DQA1~DQB1 haplotypes in individuals with type 1 diabetes mellitus and without T1D.
| Haplotypes (DRB1~DQA1~DQB1) | T1D Individuals N (%) | Individuals without T1D N(%) | OR | CI | p value |
|---|---|---|---|---|---|
| 01:01~01:01 g~05:01 | 75 (3.68%) | 315 (3.08%) | 1.2 | 0.93–1.55 | 0.16472 |
| 01:02~01:01 g~05:01 | 54 (2.65%) | 578 (5.65%) | 0.45 | 0.34–0.60 | 0.00000 |
| 01:03~01:01 g~05:01 | 4 (0.20%) | 67 (0.66%) | 0.3 | 0.11–0.82 | 0.00970 |
| 03:01~05:01 g~02:01 | 590 (28.95%) | 671 (6.56%) | 5.8 | 5.13–6.57 | 0.00000 |
| 03:02~04:01~04:02 | 10 (0.49%) | 306 (2.99%) | 0.16 | 0.08–0.30 | 0.00000 |
| 04:01~03:01 g~03:01 g | 11 (0.54%) | 74 (0.72%) | 0.74 | 0.39–1.41 | 0.45982 |
| 04:01~03:01 g~03:02 | 102 (4.99%) | 81 (0.79%) | 6.6 | 4.91–8.87 | 0.00000 |
| 04:02~03:01 g~03:02 | 130 (6.39%) | 199 (1.94%) | 3.43 | 2.74–4.31 | 0.00000 |
| 04:03~03:01 g~03:02 | 7 (0.34%) | 33 (0.32%) | 1.06 | 0.47–2.41 | 0.83218 |
| 04:04~03:01 g~03:02 | 69 (3.39%) | 100 (0.98%) | 3.55 | 2.60–4.84 | 0.00000 |
| 04:04~03:01 g~04:02 | 1 (0.05%) | 19 (0.18%) | 0.26 | 0.03–1.97 | 0.23192 |
| 04:05~03:01 g~02:02 | 11 (0.52%) | 17 (0.17%) | 3.26 | 1.52–6.98 | 0.00352 |
| 04:05~03:01 g~03:02 | 205 (10.06%) | 210 (2.05%) | 5.34 | 4.37–6.51 | 0.00000 |
| 04:06~03:01 g~04:02 | 2 (0.10%) | 36 (0.35%) | 0.28 | 0.07–1.16 | 0.07690 |
| 04:07~01:03~06:03 | 0 (0.00%) | 20 (0.20%) | |||
| 04:07~03:01 g~03:01 g | 3 (0.15%) | 58 (0.57%) | 0.26 | 0.08–0.83 | 0.00924 |
| 04:07~03:01 g~03:02 | 9 (0.44%) | 37 (0.36%) | 1.22 | 0.59–2.54 | 0.55330 |
| 04:08~03:01 g~03:01 g | 5 (0.25%) | 20 (0.19%) | 1.26 | 0.47–3.35 | 0.59360 |
| 04:11~03:01 g~03:02 | 14 (0.69%) | 258 (2.52%) | 0.27 | 0.16–0.46 | 0.00000 |
| 04:11~03:01 g~04:02 | 1 (0.05%) | 21 (0.20%) | 0.24 | 0.03–1.78 | 0.15815 |
| 07:01~02:01~02:02 | 125 (6.12%) | 1112 (10.87%) | 0.54 | 0.44–0.65 | 0.00000 |
| 07:01~02:01~03:03 | 4 (0.20%) | 166 (1.63%) | 0.12 | 0.04–0.32 | 0.00000 |
| 08:01~04:01~04:02 | 30 (1.47%) | 171 (1.67%) | 0.88 | 0.59–1.30 | 0.56217 |
| 08:02~04:01~04:02 | 6 (0.29%) | 139 (1.36%) | 0.21 | 0.09–0.49 | 0.00004 |
| 08:03~06:01~03:01 g | 1 (0.05%) | 68 (0.66%) | 0.07 | 0.01–0.53 | 0.00012 |
| 08:04~04:01~03:01 g | 9 (0.44%) | 66 (0.64%) | 0.68 | 0.34–1.37 | 0.35046 |
| 08:04~04:01~04:02 | 6 (0.29%) | 84 (0.82%) | 0.36 | 0.16–0.82 | 0.01335 |
| 08:07~04:01~04:02 | 4 (0.20%) | 52 (0.51%) | 0.38 | 0.14–1.07 | 0.06935 |
| 09:01~03:01 g~02:02 | 58 (2.86%) | 61 (0.60%) | 4.88 | 3.40–7.02 | 0.00000 |
| 09:01~03:01 g~03:03 | 11 (0.53%) | 82 (0.80%) | 0.67 | 0.36–1.26 | 0.26463 |
| 10:01~01:01 g~05:01 | 23 (1.13%) | 189 (1.84%) | 0.61 | 0.39–0.94 | 0.02799 |
| 11:01~01:02~05:02 | 1 (0.05%) | 51 (0.50%) | 0.1 | 0.01–0.71 | 0.00210 |
| 11:01~01:02~06:02 | 8 (0.39%) | 327 (3.19%) | 0.12 | 0.06–0.24 | 0.00000 |
| 11:01~01:02~06:11 | 0 (0.00%) | 22 (0.22%) | |||
| 11:01~05:01 g~03:01 g | 19 (0.93%) | 324 (3.16%) | 0.29 | 0.18–0.46 | 0.00000 |
| 11:01~05:10~03:01 g | 0 (0.00%) | 18 (0.18%) | |||
| 11:02~05:01 g~03:01 g | 12 (0.59%) | 150 (1.46%) | 0.4 | 0.22–0.72 | 0.00155 |
| 11:02~05:10~03:01 g | 1 (0.05%) | 24 (0.23%) | 0.21 | 0.03–1.54 | 0.10735 |
| 11:03~05:01 g~03:01 g | 5 (0.25%) | 50 (0.49%) | 0.5 | 0.20–1.26 | 0.14891 |
| 11:03~05:10~03:01 g | 0 (0.00%) | 21 (0.20%) | |||
| 11:04~05:01 g~03:01 g | 16 (0.79%) | 119 (1.16%) | 0.67 | 0.40–1.14 | 0.16619 |
| 12:01 g~01:01 g~05:01 | 4 (0.20%) | 58 (0.57%) | 0.34 | 0.12–0.95 | 0.02621 |
| 12:01 g~05:01 g~03:01 g | 12 (0.59%) | 35 (0.34%) | 1.73 | 0.89–3.33 | 0.11396 |
| 12:02~01:02~06:02 | 0 (0.00%) | 20 (0.20%) | |||
| 12:02~06:01~03:01 g | 0 (0.00%) | 35 (0.34%) | |||
| 13:01~01:02~05:01 | 6 (0.29%) | 32 (0.31%) | 0.94 | 0.39–2.25 | 0.99990 |
| 13:01~01:03~06:03 | 43 (2.11%) | 676 (6.60%) | 0.3 | 0.22–0.42 | 0.00000 |
| 13:01~03:01 g~03:03 | 2 (0.10%) | 17 (0.17%) | 0.59 | 0.14–2.56 | 0.75702 |
| 13:02~01:02~05:01 | 9 (0.44%) | 36 (0.35%) | 1.26 | 0.60–2.61 | 0.54621 |
| 13:02~01:02~05:02 | 3 (0.15%) | 15 (0.15%) | 1.00 | 0.29–3.47 | 0.99480 |
| 13:02~01:02~06:04 | 57 (2.80%) | 248 (2.42%) | 1.16 | 0.86–1.55 | 0.31273 |
| 13:02~01:02~06:09 | 15 (0.74%) | 122 (1.19%) | 0.61 | 0.36–1.05 | 0.08778 |
| 13:02~01:03~06:03 | 1 (0.05%) | 34 (0.34%) | 0.15 | 0.02–1.08 | 0.02212 |
| 13:03~02:01~02:02 | 0 (0.00%) | 34 (0.33%) | |||
| 13:03~05:01 g~03:01 g | 11 (0.54%) | 81 (0.79%) | 0.68 | 0.36–1.23 | 0.26351 |
| 14:02~05:01 g~03:01 g | 1 (0.05%) | 227 (2.22%) | 0.02 | 0.003–0.15 | 0.00000 |
| 14:04~01:01 g~05:03 | 4 (0.20%) | 18 (0.18%) | 1.12 | 0.38–3.30 | 0.77609 |
| 14:06~05:01 g~03:01 g | 3 (0.15%) | 43 (0.42%) | 0.35 | 0.11–1.13 | 0.07289 |
| 14:54~01:01 g~05:03 | 1 (0.05%) | 79 (0.77%) | 0.06 | 0.009–0.45 | 0.00001 |
| 15:01~01:02~05:02 | 2 (0.10%) | 18 (0.18%) | 0.56 | 0.13–2.40 | 0.55981 |
| 15:01~01:02~06:02 | 16 (0.79%) | 414 (4.04%) | 0.19 | 0.11–0.31 | 0.00000 |
| 15:02~01:03~06:01 | 2 (0.10%) | 45 (0.44%) | 0.22 | 0.05–0.92 | 0.01755 |
| 15:03~01:02~06:02 | 18 (0.88%) | 503 (4.92%) | 0.17 | 0.11–0.28 | 0.00000 |
| 16:01~01:02~05:02 | 17 (0.83%) | 212 (2.07%) | 0.4 | 0.24–0.65 | 0.00014 |
| 16:02~01:02~05:02 | 6 (0.29%) | 70 (0.68%) | 0.43 | 0.19–0.99 | 0.04314 |
| 16:02~05:01 g~03:01 g | 4 (0.20%) | 84 (0.82%) | 0.24 | 0.09–0.65 | 0.00213 |
| Others | 159 (7.80%) | 660 (6.45%) | 1.23 | 1.03–1.47 | 0.02560 |
T1D = type 1 diabetes mellitus; n = number of individuals; OR = odds ratio; CI = confidence interval; sixty-eight haplotypes with total number in patients plus controls greater than 18 were included (0.3%). P required for statistical significance after Bonferroni correction for multiple tests <0.00074. Rare alleles were included in others.