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. 2020 Apr 20;11:1908. doi: 10.1038/s41467-020-15866-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Viability and VCD, b HCP profile, c normalized HCP content on day 7, and d normalized specific HCP productivity of WT (red), 6xKO (green), 11xKO (blue), and 14xKO (gray) cell lines. Viability, VCD and HCP content were measured from day 0 to day 7 in shake flasks. The specific HCP productivity was determined as the slope of HCP concentration versus the integral number of viable cell (IVCD) calculated from day 0 to day 7, and expressed as pg HCP per cell and per day (HCP pcd). Specific HCP production was normalized to the levels detected in WT. Data are presented as mean values ± SD (n = 3 independent experiments). Statistical analysis (c, d) was performed using one-way ANOVA followed by Tukey’s post-hoc test. Source data are provided as a Source Data file.