Table 3.

Discrete measures of educational support, neurodevelopmental disorders and hearing in carriers of USH2A compared to non-carriers in UK10K dataset.

Measure	Age measured	No affected USH2A carriers	Freq in USH2A carriers	No. of affected non-carriers	Freq in non-carriers
Carer worried about child’s speech	3 years	2 of 13	0.15	120 of 1580	0.08
Child has learning difficulties requiring special arrangements at school	7 years	0 of 14	0	55 of 1548	0.04
Child has speech problems requiring special arrangements at school	7 years	0 of 14	0	13 of 1548	0.01
Child has hearing problems requiring special arrangements at school	7 years	0 of 14	0	30 of 1548	0.02
Child has eyesight problems requiring special arrangements at school	7 years	0 of 14	0	13 of 1548	0.01
Child has physical problems requiring special arrangements at school	7 years	0 of 14	0	12 of 1548	0.01
Child has reading difficulties requiring special arrangements at school	7 years	0 of 14	0	70 of 1548	0.05
Child has emotional/behavioural problems requiring special arrangements at school	7 years	0 of 14	0	22 of 1548	0.01
Child stutters/stumbles when speaks	8 years	3 of 14	0.21	119 of 1560	0.08
DAWBA DSM-IV clinical diagnosis - Any ADHD disorder	7 years	0 of 14	0	20 of 1569	0.01
Mother told child has dyslexia	9 years	1 of 12	0.08	71 of 1540	0.05
Mother told child has dyspraxia	9 years	0 of 11	0	29 of 1513	0.02
Mother told child has dyscalculia	9 years	0 of 11	0	8 of 1496	0.01
Hearing Impairment (AC thresholds greater than 20db HL at 1,2,4 kHz)	7 years	0 of 13	0	114 of 1492	0.08
OME/abnormal middle ear pressure (<−100 mm H2O)	7 years	5 of 14	0.36	422 of 1510	0.28

Fifteen binary measures of developmental difficulties were compared between individuals carrying USH2A variants that have previously been reported as pathogenic and control UK10K individuals without such variants.