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. 2020 Apr 20;11(4):252. doi: 10.1038/s41419-020-2460-x

Fig. 5. Carnosol prevents NLRP3 inflammasome activation and suppresses LPS-induced septic shock in mice.

Fig. 5

a Survival of C57BL/6 female mice treated with vehicle, MCC950 (50 mg/kg) or various doses of carnosol and then intraperitoneally injected with LPS (20 mg/kg). Survival was monitored for 60 h (n = 10). b–e ELISA of serum IL-1β (b), TNF-α (c) and quantification of peritoneal exudate cells (PECs) (d), monocytes-macrophages (F4/80+ cells) (e) from C57BL/6 female mice treated with vehicle, various doses of carnosol or MCC950 (40 mg/kg) for 1 h and then intraperitoneally injected with LPS (20 mg/kg) for 4 h. f–i Changes in body weight (f), ALT (g), AST (h) and CRE (i) levels in C57BL/6 mice treated with vehicle or carnosol (120 mg/kg) for 14 days. Data are represented as the mean ± SD. The significance of the differences was analyzed using Mann–Whitney U test or log-rank test: *P < 0.05, **P < 0.01, ***P < 0.001 vs. the control, NS, not significant.