Table 2.
The current high-resolution structures of CFTR from the Chen lab.
| Origin | Mutation | State | Resolution | Year | PDB ID |
|---|---|---|---|---|---|
| Human | – | Dephosphorylated, Apo-ATP, inward-facing | 3.87 Å | 2017 | 5UAK84 |
| Human | E1371Q | Phosphorylated, ATP-bound, outward-facing | 3.2 Å | 2018 | 6MSM68 |
| Human | E1371Q | Phosphorylated, ATP-bound, outward-facing, Ivacaftor-bound | 3.3 Å | 2019 | 6O2P70 |
| Human | E1371Q | Phosphorylated, ATP-bound, outward-facing, GLPG1837-bound | 3.2 Å | 2019 | 6O1V70 |
| Zebrafish | – | Dephosphorylated, Apo-ATP, inward-facing | 3.73 Å | 2016 | 5UAR71 |
| Zebrafish | E1372Q | Phosphorylated, ATP-bound, outward-facing | 3.37 Å | 2017 | 5W8185 |