Table 1.

Inclusion and exclusion criteria for papers to be included within the current review.

Include	Exclude
Articles where: • The study is primary literature OR a systematic review of primary literature • The population is not obtained through means of family history only • The written language is English • The paper was published between January 2008 and November 2018	Studies that: • Are unrelated to genetics • Are review papers • Discuss ethical, legal and social implications • Study epigenetic or mitochondrial disease • Define clinical management of disease • Are case studies • Use family history based penetrance only