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. 2020 Apr 20;11(4):250. doi: 10.1038/s41419-020-2413-4

Fig. 5. in vivo experiment showed miR-486-3p overexpression could enhance sorafenib effect.

Fig. 5

a Gross view of tumors from both groups; (b) Tumor size was measured every 3–5 days after lentivirus interference; (c) miRNA levels of two groups were verified using qRT-PCR; (d) Immunohistochemistry showed increased miR-486-3p level could suppress FGFR4 and EGFR level in vivo; (e) Schematic representation of the in vivo model timeline. A total of 6 mice were included in each group; (f) Functional model of the tumor suppressor miR-486-3p.