Fig. 5. in vivo experiment showed miR-486-3p overexpression could enhance sorafenib effect.
a Gross view of tumors from both groups; (b) Tumor size was measured every 3–5 days after lentivirus interference; (c) miRNA levels of two groups were verified using qRT-PCR; (d) Immunohistochemistry showed increased miR-486-3p level could suppress FGFR4 and EGFR level in vivo; (e) Schematic representation of the in vivo model timeline. A total of 6 mice were included in each group; (f) Functional model of the tumor suppressor miR-486-3p.