Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 18;36:100977. doi: 10.1016/j.molmet.2020.100977

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

HFD does not affect spontaneous inhibitory transmission to ORX or MCH neurons. (A) Representative mIPSC traces of ORX neurons from Ctrl (left) or HFD (right) rats fed for 1, 4, and 11 weeks. (B–C) Summary graphs displaying no change in the mIPSC amplitude (B; two-way ANOVA, p = 0.2618) or frequency (C; two-way ANOVA, p = 0.6794) over the course of HFD feeding compared to the Ctrl group. mIPSC amplitude decreases with age among the Ctrl groups (one-way ANOVA, p = 0.0007), while mIPSC frequency does not change (one-way ANOVA, p = 0.4699). For (A–C): †p < 0.05 for age, Sidak's multiple comparison test. n = 5–13; N = 3–5. (D) Representative mIPSC traces of MCH neurons from Ctrl (left) or HFD (right) rats fed for 1, 4, and 11 weeks. (E–F) Summary graphs displaying a lack of HFD-induced change in the mIPSC amplitude (E; two-way ANOVA, p = 0.2401) and frequency (F; two-way ANOVA, p = 0.2339) throughout the feeding period. In Ctrl groups, there were also no age-dependent changes in mIPSC amplitude (one-way ANOVA, p = 0.1879) or frequency (one-way ANOVA, p = 0.7971). For (D–F): n = 7–12 cells; N = 3–4 rats.