Table 1.
Select overview of angiotensin receptor blockers [7]
| Generic & brand | FDA indication(s) | Dose equivalent | Metabolism | Time to maximum concentration (Tmax) | Half-life | How supplied | Average wholesale price (AWP) |
|---|---|---|---|---|---|---|---|
|
Azilsartan Edarbi® |
Hypertension, alone or in combination | 40 mg | CYP2C9 | 1.5 to 3 h | 11 h | 40 mg, 80 mg tablets |
$7.48 per 40 mg tab, $8.14 per 80 mg tab |
|
Candesartan Atacand® |
Hypertension & Heart failure (HF) | 16 mg | Minor hepatic metabolism | 3 to 4 h | 9 to 12 h | 4 mg, 8 mg, 16 mg, 32 mg tablets | $3.06–3.31 per 4 mg, 8 mg, or 16 mg tab, $4.17–4.47 per 32 mg tab |
|
Eprosartan Teveten® |
Hypertension | 600 mg | Conjugation with glucuronic acid | 1 to 2 h | 5 to 9 h | 600 mg tablets | $3.43 per 600 mg tabs |
|
Irbesartan Avapro® |
Hypertension, diabetic nephropathy with an elevated serum creatinine and proteinuria (greater than 300 mg/day) in patients with diabetes and hypertension | 150 mg | CYP2C9 (major) & CYP3A4 (minor) | 1.5 to 2 h | 11 to 15 h | 75 mg, 150 mg, 300 mg tablets | $2.92–3.00 per 75 mg tab; $2.21–3.13 per 150 mg tabs; $3.69 per 300 mg tabs |
|
Olmesartan Benicar® |
Hypertension | 20 mg | De-esterified in the gastrointestinal tract | 1 to 2 h | 13 h | 5 mg, 20 mg, 40 mg tablets | $5.13–5.65 per 4 mg tab, $6.28 to 6.91 per 20 mg tab, $8.73–9.61 per 40 mg tab |
|
Losartan Cozaar® |
Hypertension, stroke prophylaxis in patients with hypertension and left ventricular hypertrophy (LVH), diabetic nephropathy with an elevated serum creatinine and proteinuria in patients with diabetes and hypertension | 50 mg | CYP2C9 (major) & CYP3A4 /CYP2C19 (minor) | 1 (parent drug) & 3 to 4 h (active metabolite) | 2 h (parent) & 6 h (active metabolite) |
25 mg, 50 mg, 100 mg tablets |
$1.67–3.08 per 25 mg tab, $2.26–2.27 per 50 mg tab, $3.08–3.10 per 100 mg tab |
|
Telmisartan Micardis® |
Hypertension, cardiovascular risk reduction in patients unable to take ACE-inhibitors | 40 mg | Conjugation | 0.5 to 1 h | 24 h | 20 mg, 40 mg, 80 mg tablets | $4.34–5.83 per 20 mg, 40 mg, or 80 mg tab |
|
Valsartan Diovan® |
Hypertension, Heart failure, reduction of cardiovascular mortality in stable patients with left ventricular failure or dysfunction following myocardial infarction (MI) | 160 mg | CYP2C9 (major) & OATP1B1/MRP2 transporters | 2 to 4 h | 6 h | 40 mg, 80 mg, 160 mg, 320 mg tablets |
$0.09–4.06 per 40 mg tab, $0.09 - 6.12 per 80 mg tab, $0.11–6.58 per 160 mg tab, $0.17–6.59 per 320 mg tab |
mg milligram, CYP cytochrome P450, ACE angiotensin converting enzyme, OAT organic anion transporter, MRP multidrug resistance protein