Table 3.

Validation study for six variants located within six genes previously reported to be associated with Buruli ulcer.

SNP	Chr	M/m	Gene	Previous candidate-gene studies						GWASa
				Study	Population	MAF	Model	OR (95% CI)	P value	MAF	OR (95% CI)	P valueb
rs1333955	6	C/T	PARK2	Capela et al.26	Benin	0.24	Dom	1.43 (1.00–2.06)	0.05	0.27	1.05 (0.64–1.69)	0.357
rs9302752	16	C/T	NOD2	Capela et al.26	Benin	0.38	Dom	2.23 (1.14–4.37)	0.02	0.40	1.10 (0.72–1.67)	0.498
rs2241880	2	A/G	ATG16L1	Capela et al.26	Benin	0.30	Rec	0.35 (0.13–0.90)	0.02	0.26	0.46 (0.25–0.86)	0.009
rs9282799	17	G/A	iNOS	Bibert et al.27	Ghana	0.08	Add	1.99 (1.22–3.26)	0.006	0.04	1.33 (0.82–2.14)	0.110
rs2069705	12	A/G	IFNG	Bibert et al.27	Ghana	0.47	Add	1.56 (1.14–1.99)	0.007	0.43	1.00 (0.82–1.22)	0.482
rs17235409	2	G/A	SCL11A1	Stienstra et al.25	Ghana	0.07	Dom	2.50 (1.26–4.96)	0.007	0.09	1.02 (0.20–5.08)	0.257

Chr chromosome, M major allele, m minor allele, MAF minor allele frequency, Dom dominant model, Rec recessive model, Add additive model.

^aResults from the GWAS sample obtained with the binary case/control phenotype under the same genetic model as the one used by the corresponding previous study.

^bP values for one-tailed tests are given for the marker alleles indicated in bold.