Table 1.
Baseline clinical and biochemical characteristics in 141 CKD 5 patients in relation to tertiles of dp-ucMGP.
| All (n = 141) | 1st tertile (n = 46) | 2nd tertile (n = 47) | 3rd tertile (n = 48) | p-value | |
|---|---|---|---|---|---|
| Age (years) | 47 (24, 63) | 43 (22, 63) | 49 (23, 62) | 50 (32, 68) | 0.008 |
| Males, (%) | 70 | 65 | 68 | 75 | 0.57 |
| Diabetes mellitus, (%) | 11 | 7 | 11 | 17 | 0.29 |
| Cardiovascular disease, (%) | 16 | 7 | 15 | 25 | 0.04 |
| BMI, (kg/m2)* | 24.5 (20.8, 29.9) | 24.0 (19.8, 29.1) | 23.5 (20.8, 30.4) | 25.1 (21.8, 30.2) | 0.17 |
| Systolic BP, (mmHg)* | 140 (117, 169) | 140 (116, 162) | 140 (116, 167) | 144 (121, 181) | 0.29 |
| Diastolic BP, (mmHg)* | 84 (69, 96) | 82 (68, 92) | 82 (72, 100) | 86 (67, 99) | 0.33 |
| Hemoglobin, (g/L)‡ | 114 (99, 132) | 111 (98, 129) | 118 (99, 135) | 113 (99, 132) | 0.09 |
| HbA1c, (mmol/mol)† | 33 (23, 40) | 35 (26, 40) | 32 (25, 40) | 32 (21, 41) | 0.06 |
| Triglycerides, (mmol/L) | 1.3 (0.7, 2.4) | 1.2 (0.6, 2.2) | 1.2 (0.7, 2.6) | 1.4 (0.7, 2.6) | 0.58 |
| Total cholesterol, (mmol/L) | 4.5 (3.1, 6.2) | 4.3 (3.0, 6.1) | 4.6 (3.2, 6.0) | 4.5 (3.0, 6.4) | 0.64 |
| HDL cholesterol, (mmol/L) | 1.4 (0.9, 2.1) | 1.4 (1.0, 2.1) | 1.4 (0.9, 2.0) | 1.3 (0.8, 2.2) | 0.37 |
| Serum Creatinine, (µmol/L) | 723 (488, 1022) | 622 (388, 985) | 743 (517, 1018) | 782 (531, 1135) | 0.01 |
| Serum Albumin (g/L)* | 35 (29, 40) | 35 (30, 42) | 35 (29, 40) | 36 (29, 41) | 0.80 |
| Uric Acid, (µmol/L)• | 369 (254, 522) | 413 (285, 557) | 350 (239, 510) | 357 (247, 469) | 0.02 |
| PEW (SGA > 1), n (%)** | 25 | 31 | 26 | 18 | 0.33 |
| Vascular calcification biomarkers | |||||
| Coronary artery calcium, (AU) ‡‡ | 8 (0, 1170) | 0 (0, 236) | 8 (0, 1392) | 34 (0, 1948) | 0.002 |
| Calcium, (mmol/L)* | 2.3 (2.0, 2.5) | 2.3 (2.1, 2.4) | 2.3 (2.0, 2.6) | 2.3 (1.9, 2.6) | 0.67 |
| Phosphate, (mmol/L)* | 1.6 (1.0, 2.4) | 1.7 (1.0, 2.2) | 1.6 (1.1, 2.5) | 1.7 (0.9, 2.5) | 0.96 |
| Glu-OC, (ng/mL)** | 14.0 (1.8, 87.6) | 7.5 (1.6, 33.7) | 15.5 (1.7, 122.6) | 37.8 (2.3, 99.2) | 0.001 |
| Gla-OC, (ng/mL)** | 33.2 (11.7, 97.6) | 26.7 (11.0, 73.5) | 33.2 (11.7, 138.0) | 42.9 (9.7, 102.2) | 0.23 |
| Mid-OC¸ (ng/mL) ¶¶¶ | 59.5 (13.5, 259.5) | 37.9 (11.6, 178.6) | 61.8 (11.3, 218.6) | 90.5 (17.7, 395.8) | 0.02 |
| Osteoprotegerin, (pg/ml) ••• | 6.1 (3.8, 12.0) | 5.6 (2.8, 10.1) | 5.9 (3.9, 11.1) | 7.6 (4.2, 14.0) | 0.002 |
Data presented as median (10th – 90th percentile) or percentage.
Abbreviations: CKD, chronic kidney disease; dp-ucMGP, dephosphorylated uncarboxylated Matrix Gla protein; BMI (body mass index); BP, blood pressure; HbA1c, Hemoglobin A1c; HDL, high-density lipoprotein; PEW, protein energy wasting; SGA, subjective global assessment; AU, Agatson unit; Glu-OC, undercarboxylated osteocalcin; Gla-OC, carboxylated osteocalcin; mid-OC, n-mid osteocalcin.
*n= 139 **n= 137 ***n= 109.
‡n= 120 ‡‡n= 110 ‡‡‡n= 103.
†n= 121 ††n= 99 †††n= 68.
¶n= 106 ¶¶n= 138 ¶¶¶n= 91.
•n= 128 ••n= 140 •••n= 114.