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. 2020 Apr 20;6:10. doi: 10.1038/s41537-020-0099-3

Table 5.

Relation between fractional anisotropy (FA) and language disturbances per ROI.

Dependent variable Significant predictor(s) B Confidence interval B (95%) Beta Adjusted R2 Anova
p (uncorr.) p (FDR corr.)
Healthy controls
 AF left Pause duration 0.037 0.004 0.071 0.318 0.753 0.000152** 0.002**
MLU 0.002 0.001 0.003 0.844
Clauses per utterance −0.606 −0.908 −0.304 −0.556
Disfluencies 0.003 0.001 0.005 0.380
Pause to word ratio −0.004 −0.006 −0.002 −0.770
 AF right MLU 0.001 0.0004 0.002 0.481 0.465 0.002** 0.004**
Clauses per utterance −0.556 −0.970 −0.143 −0.463
Pause to word ratio −0.002 −0.004 −0.001 −0.432
 IFOF left MLU 0.001 0.0004 0.002 0.528 0.418 0.005** 0.007**
Pause to word ratio −0.002 −0.004 −0.0003 −0.429
 IFOF right Speaking turn duration 0.001 0.001 0.002 0.558 0.416 0.005** 0.007**
Clauses per utterance −0.468 −0.902 −0.034 −0.401
Pause to word ratio −0.003 −0.005 −0.001 −0.466
 ILF left Speaking turn duration 0.002 0.0004 0.003 0.766 0.652 0.001** 0.003**
MLU 0.001 0.0003 0.002 0.501
Clauses per utterance −0.430 −0.763 −0.097 −0.442
Disfluencies 0.003 0.0004 0.005 0.461
Pause to word ratio −0.003 −0.005 −0.002 −0.735
 ILF right Speaking turn duration 0.002 0.001 0.003 0.591 0.329 0.017* 0.019*
 SLF left MLU 0.001 0.001 0.002 0.567 0.527 0.001** 0.003**
Clauses per utterance −0.341 −0.671 −0.010 −0.332
Pause to word ratio −0.002 −0.004 −0.001 −0.482
 SLF right Speaking turn duration 0.001 0.0004 0.002 0.512 0.463 0.002** 0.004**
Clauses per utterance −0.617 −0.978 −0.257 −0.610
Pause to word ratio −0.002 −0.004 −0.0003 −0.413
 UF left MLU 0.001 0.0002 0.002 0.435 0.388 0.008** 0.010*
Clauses per utterance −0.342 −0.683 −0.0002 −0.363
 UF right Speaking turn duration 0.001 0.00003 0.002 0.425 0.250 0.043* 0.043*
Schizophrenia patients
 AF left Pause duration 0.039 0.010 0.069 0.406 0.478 0.001** 0.003**
MLU −0.001 −0.002 −0.0003 −0.433
Noun–verb ratio −0.136 −0.240 −0.033 −0.462
 AF right Turn duration 0.002 0.0006 0.003 0.401 0.126 0.042 0.047*
Pause to word ratio 0.004 0.0002 0.007 0.612
 IFOF left Pause duration 0.030 0.006 0.053 0.393 0.464 0.002** 0.003**
Speaking turn duration 0.001 0.0001 0.003 0.401
MLU −0.001 −0.002 −0.0003 −0.451
Noun–verb ratio −0.085 −0.166 −0.003 −0.370
 IFOF right Noun–verb ratio −0.143 −0.206 −0.080 −0.763 0.509 0.001** 0.003**
Disfluencies −0.004 −0.006 −0.001 −0.541
Pause to word ratio 0.002 0.001 0.004 0.614
 ILF left Pause duration 0.029 0.008 0.051 0.410 0.494 0.001** 0.003**
Speaking turn duration 0.001 0.0002 0.002 0.414
MLU −0.001 −0.002 −0.0002 −0.426
Noun–verb ratio −0.083 −0.158 −0.008 −0.384
 ILF right Pause duration 0.020 0.0001 0.040 0.317 0.448 0.002** 0.003**
Speaking turn duration 0.001 0.0001 0.002 0.342
MLU −0.001 −0.002 −0.0002 −0.455
Noun–verb ratio −0.091 −0.160 −0.021 −0.473
 SLF left Pause duration 0.038 0.010 0.066 0.420 0.479 0.001** 0.003**
MLU −0.001 −0.002 −0.0001 −0.374
Noun–verb ratio −0.130 −0.226 −0.034 −0.474
 UF left Pause duration 0.048 0.019 0.078 0.544 0.364 0.002** 0.003**
Noun–verb ratio −0.111 −0.200 −0.022 −0.413
 UF right Pause duration 0.030 0.006 0.053 0.416 0.466 0.002** 0.003**
Noun–verb ratio −0.115 −0.191 −0.040 −0.534
Disfluencies −0.005 −0.008 −0.002 −0.636
Pause to word ratio 0.003 0.0005 0.005 0.601

Significant predictors for the DTI values are displayed. The adjusted R2 and ANOVA p-values display the fit and significance of the full model.

FDR false discovery rate, uncorr. uncorrected, corr. corrected. N/A not applicable, MLU mean length of utterance, AF arcuate fasciculus, IFOF inferior fronto-occipital fasciculus, ILF inferior longitudinal fasciculus, SLF superior longitudinal fasciculus, UF uncinate fasciculus.

*Indicates significance at the level of α = 0.05.

**Indicates significance at the level of α = 0.01. No significant model was found for the right SLF in the schizophrenia patients group, therefore this ROI is not displayed here.