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. 2020 Apr 20;11(4):249. doi: 10.1038/s41419-020-2438-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Serum-free conditioned media of m1-MDM (induced by LPS+IFNγ), m2c-MDM (induced by IL-10), and asc-MDM (induced by ascites) from the same 5 donors tested for stimulation of tumor cell migration in Fig. 1 were analyzed by mass spectrometry-based proteomics. a Pie chart showing the distribution of proteins present selectively in the medium from asc-MDM and m2c-MDM versus m1-MDM (orange), asc-MDM and m1-MDM versus m2c-MDM (pink), and asc-MDM versus m1-MDM and m2c-MDM (red). Numbers (n) refer to the identified polypeptides (feature_ids in Table S1); arrows point to the number of annotated genes that could be associated with the identified polypeptides. The respective genes (or gene functions) are listed in the colored boxes. b Dot plot showing protein levels individually (log₂ LFQ values measured by LC-MS/MS) for MDM from the same donors as in Fig. 1. Arrows indicate the following selectivities: asc & alt: asc-MDM and m2c-MDM versus m1-MDM (orange in a); asc & inf: higher level found with asc-MDM and m1-MDM versus m2c-MDM (pink in a); asc: asc-MDM versus m1-MDM and m2c-MDM (red in a); inf: m1-MDM versus asc-MDM and m2c-MDM; alt: m2c-MDM versus m1-MDM and m2c-MDM. The table at the bottom shows p values (paired t test) for the relevant comparisons. Green: p < 0.05; gray p ≥ 0.05.