Table 2.
Alleles, genotype and haplotypes of inflammasome gene and the risk of RCC.
| Alleles and haplotypes of NLRP3 | RCC Cases (n = 350) | Controls (n = 700) | Crude ORs (95% CI) | Multivariate adjusted ORs (95% CI)a |
|---|---|---|---|---|
| SNP1: rs4925654 | ||||
| G | 589 (84.63) | 1192 (85.26) | 1.00 | 1.00 |
| A | 107 (15.37) | 206 (14.74) | 1.05 (0.82–1.36) | 1.12 (0.85–1.47) |
| GG | 250 (71.84) | 509 (72.82) | 1.00 | 1.00 |
| GA | 89 (25.57) | 174 (24.89) | 1.04 (0.78–1.40) | 1.09 (0.79–1.51) |
| AA | 9 (2.59) | 16 (2.29) | 1.17 (0.51–2.68) | 1.36 (0.56–3.30) |
| SNP2: rs4925650 | ||||
| G | 357 (51.00) | 761 (54.36) | 1.00 | 1.00 |
| A | 343 (49.00) | 639 (45.64) | 1.14 (0.95–1.37) | 1.12 (0.92–1.37) |
| GG | 97 (27.71) | 203 (29.00) | 1.00 | 1.00 |
| GA | 163 (46.57) | 355 (50.71) | 0.97 (0.71–1.31) | 1.00 (0.71–1.39) |
| AA | 90 (25.71) | 142 (20.29) | 1.34 (0.93–1.91) | 1.27 (0.86–1.87) |
| SNP3: rs12239046 | ||||
| T | 267 (38.25) | 590 (42.14) | 1.00 | 1.00 |
| C | 431 (61.75) | 810 (57.86) | 1.18 (0.98–1.42)+ | 1.20 (0.98–1.47)+ |
| CC | 136 (38.97) | 236 (33.71) | 1.00 | 1.00 |
| CT | 159 (45.56) | 338 (48.29) | 0.82 (0.62–1.09) | 0.84 (0.62–1.14) |
| TT | 54 (15.47) | 126 (18.00) | 0.74 (0.51–1.09) | 0.71 (0.47–1.07) |
| SNP4: rs4925648 | ||||
| T | 169 (24.14) | 353 (25.21) | 1.00 | 1.00 |
| C | 531 (75.86) | 1047 (74.79) | 1.06 (0.86–1.31) | 1.04 (0.83–1.30) |
| CC | 203 (58.00) | 398 (56.86) | 1.00 | 1.00 |
| CT | 125 (35.71) | 251 (35.86) | 0.97 (0.74–1.28) | 1.03 (0.77–1.39) |
| TT | 22 (6.29) | 51 (7.29) | 0.83 (0.49–1.41) | 0.83 (0.46–1.47) |
| SNP5: rs10925025 | ||||
| A | 267 (38.25) | 588 (42.30) | 1.00 | 1.00 |
| G | 431 (61.75) | 802 (57.70) | 1.18 (0.98–1.43)+ | 1.20 (0.98–1.47)+ |
| AA | 53 (15.19) | 125 (17.99) | 1.00 | 1.00 |
| AG | 161 (46.13) | 338 (48.63) | 1.13 (0.78–1.65) | 1.21 (0.81–1.81) |
| GG | 135 (38.68) | 232 (33.38) | 1.37 (0.93–2.02) | 1.43 (0.95–2.17)+ |
| SNP6: rs1539019 | ||||
| A | 265 (37.86) | 585 (41.91) | 1.00 | 1.00 |
| C | 435 (62.14) | 811 (58.09) | 1.18 (0.98–1.43)+ | 1.21 (0.99–1.48)+ |
| CC | 138 (39.43) | 237 (33.95) | 1.00 | 1.00 |
| CA | 159 (45.43) | 337 (48.28) | 0.82 (0.62–1.08) | 0.83 (0.61–1.13) |
| AA | 53 (15.14) | 124 (17.77) | 0.73 (0.50–1.08) | 0.70 (0.46–1.05)+ |
| SNP7: rs3806265 | ||||
| C | 300 (42.86) | 653 (46.64) | 1.00 | 1.00 |
| T | 400 (57.14) | 747 (53.36) | 1.17 (0.97–1.40) | 1.15 (0.94–1.40) |
| TT | 112 (32.00) | 200 (28.57) | 1.00 | 1.00 |
| TC | 176 (50.29) | 347 (49.57) | 0.90 (0.67–1.21) | 0.92 (0.67–1.27) |
| CC | 62 (17.71) | 153 (21.86) | 0.72 (0.49–1.04) + | 0.74 (0.49–1.11) |
| SNP8: rs10925026 | ||||
| C | 267 (38.14) | 587 (42.05) | 1.00 | 1.00 |
| A | 433 (61.86) | 809 (57.95) | 1.18 (0.98–1.42)+ | 1.20 (0.98–1.47)+ |
| CC | 53 (15.14) | 125 (17.91) | 1.00 | 1.00 |
| CA | 161 (46.00) | 337 (48.28) | 1.14 (0.78–1.65) | 1.21 (0.81–1.81) |
| AA | 136 (38.86) | 236 (33.81) | 1.36 (0.93–2.00) | 1.42 (0.94–2.15)+ |
| SNP9: rs10157379 | ||||
| C | 268 (38.29) | 589 (42.19) | 1.00 | 1.00 |
| T | 432 (61.71) | 807 (57.81) | 1.18 (0.98–1.42) | 1.20 (0.98–1.46)+ |
| CC | 53 (15.14) | 124 (17.77) | 1.00 | 1.00 |
| CT | 162 (46.29) | 341 (48.85) | 1.12 (0.77–1.63) | 1.20 (0.80–1.79) |
| TT | 135 (38.57) | 233 (33.38) | 1.36 (0.92–2.00) | 1.42 (0.94–2.14) |
| SNP10: rs12143966 | ||||
| G | 307 (44.62) | 679 (49.20) | 1.00 | 1.00 |
| A | 381 (55.38) | 701 (50.80) | 1.20 (1.00–1.44)+ | 1.22 (1.00–1.49)+ |
| GG | 70 (20.35) | 175 (25.36) | 1.00 | 1.00 |
| GA | 167 (48.55) | 329 (47.68) | 1.27 (0.91–1.77) | 1.39 (0.97–2.00)+ |
| AA | 107 (31.10) | 186 (26.96) | 1.43 (0.99–2.06) + | 1.50 (1.01–2.22) |
| SNP11: rs10754555 | ||||
| G | 259 (37.00) | 552 (39.43) | 1.00 | 1.00 |
| C | 441 (63.00) | 848 (60.57) | 1.11 (0.92–1.34) | 1.10 (0.89–1.34) |
| CC | 147 (42.00) | 261 (37.29) | 1.00 | 1.00 |
| CG | 147 (42.00) | 326 (46.57) | 0.80 (0.61–1.06) | 0.84 (0.62–1.13) |
| GG | 56 (16.00) | 113 (16.14) | 0.87 (0.60–1.27) | 0.89 (0.59–1.34) |
| SNP12: rs3806268 | ||||
| G | 298 (42.57) | 651 (46.50) | 1.00 | 1.00 |
| A | 402 (57.43) | 749 (53.50) | 1.17 (0.98–1.41)+ | 1.15 (0.94–1.40) |
| AA | 113 (32.29) | 203 (29.00) | 1.00 | 1.00 |
| AG | 176 (50.29) | 343 (49.00) | 0.92 (0.68–1.23) | 0.95 (0.69–1.30) |
| GG | 61 (17.43) | 154 (22.00) | 0.70 (0.48–1.03) | 0.74 (0.49–1.11) |
| SNP13: rs12048215 | ||||
| G | 207 (29.57) | 447 (31.93) | 1.00 | 1.00 |
| A | 493 (70.43) | 953 (68.07) | 1.12 (0.92–1.36) | 1.98 (0.88–1.35) |
| AA | 176 (50.29) | 331 (47.29) | 1.00 | 1.00 |
| AG | 141 (40.29) | 291 (41.57) | 0.91 (0.70–1.20) | 0.95 (0.71–1.28) |
| GG | 33 (9.43) | 78 (11.14) | 0.78 (0.50–1.23) | 0.81 (0.50–1.31) |
| NLRP3 block 1: NLRP3 rs10925025 and NLRP3 rs1539019 | ||||
| A-A | 265 (37.86) | 585 (41.79) | 0.85 (0.70–1.02) | 0.83 (0.68–1.02)+ |
| A-C | 2 (0.29) | 4 (0.29) | 0.93 (0.17–5.12) | 1.21 (0.21–7.09) |
| G-A | 0 | 2 (0.14) | ||
| G-C | 433 (61.86) | 809 (57.79) | 1.00 | 1.00 |
| NLRP3 block 2: NLRP3 rs10925026, NLRP3 rs10157379, and NLRP3 rs12143966 | ||||
| A-C-A | 1 (0.14) | 3 (0.21) | 0.61 (0.06–5.87) | 0.76 (0.07–8.30) |
| A-C-G | 0 | 1 (0.07) | ||
| A-T-A | 387 (55.29) | 706 (50.50) | 1.00 | 1.00 |
| A-T-G | 45 (6.43) | 101 (7.22) | 0.81 (0.56–1.18) | 0.80 (0.54–1.20) |
| C-C-G | 267 (38.14) | 587 (41.99) | 0.83 (0.69–1.00)+ | 0.82 (0.66–1.00)+ |
| NLRP3 block 3: NLRP3 rs3806268 and NLRP3 rs12048215 | ||||
| A-A | 397 (56.71) | 743 (53.07) | 1.00 | 1.00 |
| A-G | 5 (0.71) | 6 (0.43) | 1.56 (0.47–5.14) | 2.09 (0.55–7.91) |
| G-A | 96 (13.71) | 210 (15.00) | 0.86 (0.65–1.12) | 0.88 (0.65–1.17) |
| G-G | 202 (28.86) | 441 (31.50) | 0.86 (0.70–1.05) | 0.88 (0.70–1.10) |
| NLRP3 Five Tag-SNPs | ||||
| A-A-A-G-A | 0 | 1 (0.07) | ||
| A-A-G-G-A | 0 | 1 (0.07) | ||
| A-C-G-A-A | 211 (30.14) | 448 (32.00) | 1.00 | 1.00 |
| A-C-G-A-G | 4 (0.57) | 6 (0.43) | 1.42 (0.40–5.07) | 1.74 (0.41–7.38) |
| A-C-G-G-A | 31 (4.43) | 65 (4.64) | 1.01 (0.64–1.60) | 0.96 (0.58–1.57) |
| A-C-G-G-G | 19 (2.71) | 66 (4.71) | 0.61 (0.36–1.05)+ | 0.64 (0.36–1.13) |
| C-A-A-A-A | 149 (21.29) | 220 (15.71) | 1.44 (1.10–1.87) | 1.44 (1.08–1.92)* |
| C-A-A-A-G | 1 (0.14) | 0 | ||
| C-A-A-G-A | 64 (3.05) | 139 (9.93) | 0.98 (0.70–1.37) | 1.04 (0.72–1.50) |
| C-A-A-G-G | 174 (24.86) | 350 (25.00) | 1.06 (0.83–1.35) | 1.07 (0.82–1.40) |
| C-A-G-A-A | 37 (5.29) | 75 (5.36) | 1.05 (0.68–1.60) | 1.05 (0.66–1.65) |
| C-A-G-G-G | 8 (1.14) | 25 (1.79) | 0.68 (0.30–1.53) | 0.71 (0.29–1.76) |
| C-C-G-G-A | 1 (0.14) | 4 (0.29) | 0.53 (0.06–4.78) | 0.64 (0.07–6.25) |
| C-C-G-G-G | 1 (0.14) | 0 | ||
| C-A-A-A-A | 149 (21.29) | 220 (15.71) | 1.45 (1.15–1.83) | 1.43 (1.11–1.84)* |
| others | 551 (78.71) | 1180 (84.29) | 1.00 | 1.00 |
+0.05 ≤ P < 0.1 and *P < 0.05.
aModel was adjusted by age, sex, education, cumulative cigarette smoking, alcohol consumption, diabetes, and hypertension.
NLRP3 Five Tag-SNPs: rs1539019, rs10925026, rs12143966, rs3806268, and rs12048215.