TABLE 2.
Top 25 upregulated genes based on FDR in the challenged-only group compared to the vaccinated-and-challenged groupa
| Gene symbol | Gene name | FC | FDR |
|---|---|---|---|
| MHC proteins | |||
| DMB2 | Major histocompatibility complex, class II, DM beta 2 | 4.096815 | 1.29e-05 |
| BF1 | MHC BF1 class I | 2.643041 | 1.48e-05 |
| Cytokine receptors and immune signaling | |||
| IL4I1 | Interleukin 4 induced 1 | 8.984358 | 9.92e-06 |
| IL13RA2 | Interleukin 13 receptor subunit alpha 2 | 5.445273 | 1.02e-05 |
| IL2RG | Interleukin 2 receptor subunit gamma | 5.263067 | 9.92e-06 |
| TNFRSF13B | TNF receptor superfamily member 13B | 5.124457 | 2.21e-05 |
| IFITM1 | Interferon-induced transmembrane protein 1 | 4.537843 | 6.94e-06 |
| EXFABP | Extracellular fatty acid-binding protein | 4.464134 | 8.39e-06 |
| POU2AF1 | POU class 2 associating factor 1 | 4.298379 | 8.46e-06 |
| Immunoglobulin-related proteins | |||
| MZB1 | Marginal zone B and B1 cell-specific protein | 6.723834 | 4.32e-06 |
| IGLL1 | Immunoglobulin lambda-like polypeptide 1 | 4.885844 | 3.29e-06 |
| JCHAIN | Joining chain of multimeric IgA and IgM | 3.837216 | 6.94e-06 |
| Chemotaxis, phagocytosis, cell killing | |||
| SRGN | Serglycin | 6.127048 | 8.79e-06 |
| BIN2 | Bridging integrator 2 | 5.362242 | 9.78e-06 |
| Degradation of extracellular matrix | |||
| MMP7 | Matrix metallopeptidase 7 | 10.28887 | 7.24e-06 |
| MMP9 | Matrix metallopeptidase 9 | 4.309264 | 2.45e-05 |
| Other | |||
| KCNMB1 | Potassium calcium-activated channel subfamily M regulatory beta subunit 1 | 5.451376 | 1.62e-05 |
| BLVRA | Biliverdin reductase A | 4.738442 | 1.94e-05 |
| TXNDC5 | Thioredoxin domain containing 5 | 4.19952 | 4.54e-06 |
| DGUOK | Deoxyguanosine kinase | 3.768688 | 2.45e-05 |
| GBP | Guanylate-binding protein 4-like | 3.558826 | 2.03e-05 |
| KPNA2 | Karyopherin subunit alpha 2 | 3.378235 | 7.24e-06 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | 3.273998 | 1.13e-05 |
| LMAN1 | Lectin, mannose binding 1 | 3.271608 | 7.24e-06 |
| MANF | Cerebral dopamine neurotrophic factor | 3.120726 | 2.58e-05 |
a
FC, log2 fold change. A false discovery rate (FDR) of < 0.01 was considered significant.