TABLE 6.
Reactome pathways enriched with downregulated genes in the challenged-only group compared with the vaccinated-and-challenged groupa
| Pathway | Log2 fold enrichment | FDR |
|---|---|---|
| Cell organelle formation | ||
| Intraflagellar transport | 6.36 | 1.26e-09 |
| Cilium assembly | 4.31 | 1.49e-16 |
| Cargo trafficking to the periciliary membrane | 4.22 | 3.91e-03 |
| Organelle biogenesis and maintenance | 3.73 | 3.47e-14 |
| Anchoring of the basal body to the plasma membrane | 2.95 | 2.16e-03 |
| Metabolism of RNA | ||
| Metabolism of RNA | 0.12 | 1.04e-09 |
| Processing of capped intron-containing pre-mRNA | 0.1 | 6.06e-04 |
| Gene expression | ||
| Gene expression (transcription) | 0.47 | 1.32e-03 |
| Metabolism of proteins | ||
| Translation | 0.06 | 5.96e-04 |
| Cell cycle | ||
| Cell cycle checkpoints | 0.1 | 6.05e-04 |
a
A false discovery rate (FDR) of <0.01 was considered significant.