TABLE 7.
Panther protein classes enriched with up- and downregulated genes in the challenged-only group compared with the vaccinated-and-challenged groupa
| Protein class | Log2 fold enrichment | FDR |
|---|---|---|
| Upregulated | ||
| Defense/immunity protein | 6.17 | 1.05e-11 |
| Cytokine | 6.83 | 4.38e-07 |
| Chemokine | 12.95 | 3.24e-06 |
| Immunoglobulin receptor superfamily | 10.49 | 5.04e-05 |
| Immunoglobulin | 24.97 | 4.73e-04 |
| Major histocompatibility complex antigen | 12.34 | 1.09e-03 |
| Signaling molecule | 2.1 | 2.55e-03 |
| Downregulated | ||
| Nucleic acid binding | 0.46 | 2.65e-10 |
| Microtubule family cytoskeletal protein | 2.5 | 1.74e-06 |
| Cytoskeletal protein | 1.92 | 2.12e-06 |
| DNA binding protein | 0.29 | 4.55e-06 |
| RNA binding protein | 0.37 | 2.78e-05 |
| G-protein modulator | 2.03 | 6.29e-04 |
| Guanyl-nucleotide exchange factor | 2.81 | 4.57e-03 |
| Microtubule binding motor protein | 3.03 | 8.99e-03 |
a
A false discovery rate (FDR) of <0.01 was considered significant.