Plasma biomarkers of endothelial activation over time for the P. falciparum-inoculated group (n = 15). (A) OPG concentration (P = 0.015); (B) Ang-2 concentration (P = 0.020); (C) vWF concentration (P = 0.016); (D) platelet count (P < 0.001). Gray lines, individual participant results; black lines, median results; filled data points, value for the individual participant on the day of treatment; *, P < 0.05 for the paired comparison of the participant results at baseline and on the day of treatment. Abbreviations: OPG, osteoprotegerin; Ang-2, angiopoietin 2; vWF, von Willebrand factor; DOT, day of treatment.