Table 3.
Stratification analysis of risk genotypes with endometrial cancer susceptibility
Variables |
rs591291 (cases/controls) |
AOR (95% CI)a | P a |
rs664589 (cases/controls) |
AOR (95% CI)a | P a |
rs4102217 (cases/controls) |
AOR (95% CI) a | P a | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AA | AG/GG | CG/CC | GG | AA/AC | CC | |||||||
Surgery history | ||||||||||||
Yes | 45/77 | 8/17 | 0.81 (0.32‐2.02) | .644 | 50/92 | 3/2 | 2.76 (0.45‐17.06) | .275 | 52/92 | 1/2 | 0.89 (0.08‐9.99) | .921 |
No | 168/301 | 28/49 | 1.02 (0.62‐1.69) | .927 | 190/350 | 6/2 | 5.53 (1.11‐27.64) | .037 | 192/345 | 4/6 | 1.20 (0.33‐4.30) | .782 |
Menopause | ||||||||||||
Yes | 141/228 | 24/37 | 1.05 (0.60‐1.83) | .866 | 158/2657 | 7/0 | – | – | 164/258 | 1/6 | 0.26 (0.03‐2.20) | .217 |
No | 72/150 | 12/29 | 0.86 (0.42‐1.79) | .690 | 82/177 | 2/4 | 1.08 (0.19‐6.02) | .929 | 80/179 | 4/2 | 4.48 (0.80‐24.93) | .087 |
Delivery | ||||||||||||
=0 | 5/4 | 1/0 | – | – | 6/4 | 0/0 | – | – | 6/4 | 0/0 | – | – |
=1 | 57/5 | 85/13 | 0.57 (0.19‐1.70) | .315 | 60/97 | 2/1 | 3.23 (0.29‐36.43) | .342 | 62/97 | 0/1 | – | – |
≥2 | 151/289 | 30/53 | 1.08 (0.66‐1.77) | .748 | 174/341 | 7/3 | 4.57 (1.17‐17.90) | .029 | 176/336 | 5/7 | 1.36 (0.43‐4.36) | .601 |
BMI | ||||||||||||
<18.5 | 18/26 | 3/1 | 4.33 (40.42‐45.06) | .220 | 21/27 | 0/0 | – | – | 21/27 | 0/0 | – | – |
18.5 ≤ BMI ≤ 24.9 | 96/204 | 17/43 | 0.84 (0.46‐1.55) | .677 | 111/246 | 2/2 | 2.22 (0.31‐15.93) | .429 | 112/241 | 1/6 | 0.36 (0.04‐3.01) | .345 |
25.0 ≤ BMI ≤ 29.9 | 76/123 | 13/19 | 1.11 (0.52‐2.37) | .793 | 83/141 | 6/2 | 5.10 (1.01‐25.83) | .049 | 86/141 | 3/2 | 2.46 (0.40‐15.01) | .330 |
30.0 ≤ BMI ≤ 40 | 19/16 | 3/3 | 0.84 (0.15‐4.76) | .846 | 21/19 | 1/0 | 21/19 | 1/0 | – | – | ||
FIGO stage | ||||||||||||
I | 190/378 | 23/378 | 0.90 (0.56‐1.45) | .675 | 211/422 | 8/4 | 4.00 (1.18‐13.61) | .027 | 214/437 | 5/8 | 1.40 (0.45‐4.35) | .566 |
II | 29/66 | 7/66 | 1.82 (0.72‐4.57) | .203 | 29/422 | 1/4 | 15.4 (1.06‐224.76) | .046 | 30/437 | 0/8 | – | – |
Abbreviations: AOR, adjusted odds ratio; CI, confidence interval.
Adjusted for surgery history, menopause, delivery, and BMI.
The results were in bold, if the 95% CI excluded 1 or P < .05.