Figure 5.

Tigecycline inhibits tumorigenicity and enhances chemosensitivity to gemcitabine in vivo. A, The tumour weights of the xenograft tumours in each group. B, The tumour volumes of the xenograft in each group, Scale bar: 1 cm, and the in vivo growth curves of xenograft tumours treated with tigecycline, gemcitabine alone and combined with each other. C, The weight of mice body was measured in each group. D, Haematoxylin and eosin (H&E) staining and immunohistochemical staining for Ki67 were performed. Scale bar = 100 μm. E, Effects of tumours on cell proliferation (Ki67) treated with tigecycline, gemcitabine alone and combined with each other in AsPC‐1 cells. All experiments were repeated at least three times. All data were shown as the mean ± SD. Student's t test was carried out. **P < .01; ***P < .001. P‐value <.05 was considered as statistically significant