Supplemenatry Table 1.

The hub genes in the PPI network.

Group 1			Group 2			Group 3			Group 4
Gene	Degree	Type	Gene	Degree	Type	Gene	Degree	Type	Gene	Degree	Type
TRIM25	329	Up	KIAA1429	1056	Down	TRIM25	313	Up	RNF4	112	Down
MYC	317	Down	TRIM25	796	Up	RNF4	185	Down	UBC	111	Up
APP	269	Up	MYC	713	Down	COPS5	110	Down	RNF2	77	Down
XPO1	206	Down	ELAVL1	697	Down	MEPCE	91	Down	SUZ12	66	Down
RNF4	203	Down	RECQL4	520	Up	HDAC1	89	Down	CYLD	60	Down

Group 1: the PPI network analysis of DEGs between sepsis and normal controls from blood samples; Group 2: the PPI network analysis of DEGs between septic shock and normal controls from blood samples; Group 3: the PPI network analysis of DEGs between sepsis and normal controls from neutrophil samples; Group 4: the PPI network analysis of DEGs between septic shock and normal controls from neutrophil samples. PPI – protein–protein interaction; DEGs – differentially expressed genes; Up represents the upregulation of the gene and Down represents the downregulation of the gene.