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Model-based prediction of infliximab concentrations with different dosing strategies in a simulated standard patient (weight 65 kg, ALB 3.5 g/dL, ATI <22 ng/mL, ESR 9 mm/h). The green line denotes an IFX target concentration of 5 µg/mL. A, A fixed interval of 8 weeks and IFX doses of 5 mg/kg, 7.5 mg/kg, and 10 mg/kg, respectively. B, A fixed IFX dose of 5 mg/kg and intervals of 4, 6, and 8 weeks, respectively.
