Figure 1-10.

Acute Cell Swelling, Liver, Mouse.

A, Hepatic swelling in a mouse exposed to chloroform 24 hours previously. The accentuated lobular pattern and slight pallor in the liver on the left are the result of acute cell swelling (hydropic degeneration) and necrosis of centrilobular hepatocytes. The right liver is normal. B, Liver from a mouse with chloroform toxicosis. Although many hepatocytes in the centrilobular areas (at right) are necrotic, several cells at the interface of normal and necrotic (arrows) are still undergoing acute cell swelling (hydropic degeneration). H&E stain.

(Courtesy Dr. L.H. Arp.)