Table 5.
Required investigations for searching the primary site 4.
| Clinicopathological data | Work-up for all patients | Work-up for selected patients |
|---|---|---|
| Histologically confirmed metastatic cancer | Full blood count | Mammography (for all women) and breast MRI |
| Detailed medical history | Biochemistry | Testicular ultrasonography |
| Complete physical (including pelvic and rectal) examination | Urinalysis and occult blood in stools | PET or CT scan and endoscopy |
| Histopathology review with specific IHC study | Chest radiography and CT scan of thorax, abdomen and pelvis | Concentrations of serum α-Fetoprotein, β human Chorionic Gonadotropin, Prostate-Specific Antigen (for all men), Cancer Antigen 125 and Carcinoma Antigen 15-3 |
MRI; Magnetic resonance imaging. PET; positron emission tomography. CT; computerized tomography.
IHC; Immunohistochemistry.