Table 2.
Univariate and multivariate analyses of OS in ICGC-LIRI-JP (n=203) cohort by Cox regression analysis
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | CI (95%) | P value | HR | CI (95%) | P value | ||
| Age (years) | 0.922 | 0.325-2.616 | 0.878 | ||||
| Gender | 0.536 | 0.265-1.083 | 0.082 | ||||
| Virus (HBV or/and HCV) | 1.654 | 0.506-5.408 | 0.406 | ||||
| TNM stage | 2.830 | 1.446-5.540 | 0.002* | ||||
| Portal vein invasion | 3.135 | 1.595-6.160 | 0.001* | 2.395 | 1.109-5.169 | 0.026* | |
| Vein invasion Bile duct invasion |
2.394 0.531 |
1.172-4.891 0.072-3.890 |
0.017* 0.533 |
||||
| Fibrosis | 1.158 | 0.276-4.853 | 0.841 | ||||
| Alcohol | 0.476 | 0.242-0.936 | 0.031* | 0.390 | 0.193-0.786 | 0.009* | |
| Smoking | 0.758 | 0.391-1.471 | 0.413 | ||||
| HMGB1 | 2.162 | 1.098-4.255 | 0.026* | 2.192 | 1.102-4.363 | 0.025* | |
Abbreviations: HBV, hepatitis B virus; HCV, hepatitis C virus; CI, confidence interval; HR, hazard radio; *The values had statistically significant differences.