Table 2.
Univariate and multivariate analysis of association of clinicopathologic features with 5-year survival in colon cancer
| Variable | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| Relative risk | 95% CI | P Value | Relative risk | 95% CI | P Value | ||
| Age at diagnosis | 1.063 | 1.037, 1.068 | 0.026 | 1.085 | 1.042, 1.082 | 0.007 | |
| Gender | |||||||
| Male | 1.000(Ref.) | ||||||
| Female | 0.847 | 0.487, 1.212 | 0.535 | ||||
| Tumor anatomical location | |||||||
| Right hemicolon cancer | 1.000(Ref.) | ||||||
| Left hemicolon cancer | 0.653 | 0.515, 1.164 | 0.361 | ||||
| T stage | |||||||
| T1 | 0.021 | 0.000, > 105 | 0.892 | ||||
| T2 | 0.561 | 0.756, 3.251 | 0.294 | ||||
| T3 | 0.975 | 0.597, 1.579 | 0.977 | ||||
| T4 | 1.000(Ref.) | ||||||
| N stage | |||||||
| N0 | 1.000(Ref.) | ||||||
| N1 | 1.218 | 0.627, 2.420 | 0.534 | ||||
| N2 | 1.527 | 0.875, 3.087 | 0.135 | ||||
| M stage | |||||||
| M0 | 1.000(Ref.) | 1.000(Ref.) | |||||
| M1 | 1.531 | 0.912, 3.142 | 0.029 | 1.854 | 0.967, 3.238 | 0.037 | |
| TNM stage | |||||||
| I | 1.000(Ref.) | ||||||
| II | 0.573 | 0.256, 1.387 | 0.235 | ||||
| III | 0.674 | 0.295, 1.765 | 0.474 | ||||
| IV | 1.264 | 0.445, 2.789 | 0.847 | ||||
| Differentiation | |||||||
| Well | 1.000(Ref.) | 1.000(Ref.) | |||||
| Moderate | 0.901 | 0.567, 1.723 | 0.723 | 1.327 | 0.573, 1.658 | 0.256 | |
| poor/undifferentiated | 2.362 | 1.406, 4.621 | 0.002 | 1.653 | 0.785, 2.973 | 0.056 | |
| αvβ8 | |||||||
| Negative | 1.000(Ref.) | 1.000(Ref.) | |||||
| Positive | 2.224 | 1.280, 3.675 | <0.001 | 1.681 | 0.976, 3.109 | 0.031 | |