Table 3.

Association between Shh, Ptch1, Smo and Gli1 expression and clinicopathological parameters of patients with GC.

Variables	Cases (n)	Shh		P value	Ptch1		P value	Smo		P value	Gli1		P value
		Positive	Negative		Positive	Negative		Positive	Negative		Positive	Negative
Gender				0.723			0.390			0.222			0.976
Male	128	93	35		88	40		69	59		95	33
Female	50	35	15		31	19		32	18		37	13
Age (years)				0.609			0.188			0.866			0.588
<60	126	92	34		88	38		72	54		92	34
≥60	52	36	16		31	21		29	23		40	12
Tumor size (cm)				0.484			0.271			0.310			0.564
<5	71	49	22		47	24		37	34		51	20
≥5	107	79	28		72	35		64	43		81	26
Histological differentiation				0.012			0.002			0.513			0.047
Differentiated	60	36	24		31	29		32	28		39	21
Undifferentiation	118	92	26		88	30		69	49		93	25
Serosal invasion				0.042			0.038			0.620			0.000
Negative	33	19	14		17	16		20	13		16	17
Positive	145	109	36		102	43		81	64		116	29
Lymph node metastasis				0.040			0.026			0.023			0.012
Negative	45	27	18		24	21		20	25		27	18
Positive	133	101	32		95	38		81	52		105	28
TNM stage				0.019			0.018			0.030			0.004
Ⅰ+Ⅱ	52	31	21		28	24		23	29		31	21
Ⅲ	126	97	29		91	35		78	48		101	25