Table 2.
Potential plasma biomarkers associated with ESCC.
| AUC | ||||||
|---|---|---|---|---|---|---|
| metabolites | VIP | adj p | FC | training set | validation set | biological pathway |
| Hypoxanthine | 4.41 | 4.05E-08 | 0.46 | 0.794 | 0.780 | Purine metabolism |
| Proline betaine | 2.95 | 4.10E-07 | 0.29 | 0.763 | 0.670 | Amino acids metabolism |
| Indoleacrylic acid | 6.20 | 1.17E-21 | 0.63 | 0.913 | 0.677 | Amino acids metabolism |
| Inosine | 2.51 | 1.33E-08 | 0.18 | 0.895 | 0.619 | Purine metabolism |
| 9-Decenoylcarnitine | 6.60 | 7.34E-19 | 0.34 | 0.944 | 0.873 | Fatty acids metabolism |
| Tetracosahexaenoic acid | 1.70 | 1.77E-10 | 0.17 | 0.904 | 0.781 | Fatty acids metabolism |
| LPE(20:4) | 3.32 | 1.59E-03 | 1.25 | 0.668 | 0.666 | phospholipid metabolism |
| LPC(20:5) | 12.60 | 2.41E-07 | 0.75 | 0.769 | 0.770 | phospholipid metabolism |
Abbreviations: ESCC, esophageal squamous cell carcinoma; AUC, area under the curve; VIP, variable importance in the projection; adj p, adjusted p value; FC, fold change; LPC, lysophosphatidylcholine; LPE, lysophosphatidylethanolamine.