Table 1.

miRNAs involved in NPC radioresistance

miRNA	Expression	Source	Targets or Pathway	Function	References
miR-19b-3p	up	cell and tissue	Bcl-2,Bax, Capase3, c-Capase3, TNFAIP3(A20)/ NF-κB	cell apoptosis↓	6
miR-125b	up	tissue	p-p65, γ-H2AX TNFAIP3 (A20)/ NF-κB	cell apoptosis↓	29
miR-21	up	cell and tissue	Bcl-2 , Bax, PTEN/AKT	cell survival↑, cell apoptosis↓	49, 91
miR-205	up	cell	Bcl-2 , Bax, snail, PTEN/AKT	cell survival↑, cell apoptosis↓	41
EBV-miR-BART8-3p, BART5-5p, BART7-3p, BART9-3p, BART14-3p	up	cell and tissue	γ-H2AX, ATM	DDR↑, cell apoptosis↓	31, 64, 72
miR-23a	down	cell and tissue	γH2AX, IL-8 / Stat3	DDR↓, cell cycle↓, cell apoptosis↑	77
miR-203	down	tissue	γH2AX, IL-8 / Stat3	DDR↓, cell cycle↓, cell apoptosis↑	81
miR-20a-5p	up	cell	γH2AX,Rab27B, NPAS2	cell survival↑, cell apoptosis↓	43, 44
miR-193a-3p	up	cell	SRSF2	cell cycle↓	45
miR-24	down	tissue	SP1	DDR↓	65
miR-26a	down	cell and tissue	CDK4,CDK6, EZH2	cell cycle↓	76
miR-135a	down	cell	IL-17	inflammation↓, cell apoptosis↑	82
miR-143	down	cell and tissues	capase3,PARP, γH2AX	DDR↓	87

'↑' and '↓' stand for the miRNA inhibiting or promoting the function, respectively.