Table 2.
Characteristic | PD-1 DNR CAR T cells | CPB Agents with CAR T cells |
---|---|---|
Mechanism | Cell-intrinsic | Cell-extrinsic |
Potential doses | Single | Multiple doses of CPB |
Targeted therapy | Yes | No |
Potential toxicity | Localized to tumor | Systemic |
Limits to tumor penetration | Unlikely | Limits of antibody penetration |
Antigen responsiveness | Multiple | Multiple |