Table 1. NCI-60 Activity of the Active Principles of C17747 Haliclona chrysa Extract (2) and C15373 Hexabranchus sanguineus Extract (5–9)a.
compound | GI50 (μM) | yield of crude (%) | yield of subfraction (%) |
---|---|---|---|
2 | 6.76 | 3.7 | 100 |
5 | 6.76 | 0.12 | 23.33 |
6 | 4.37 | 0.21 | 19.35 |
7 | 0.40 | 0.09 | 17.78 |
8 | 0.18 | 0.15 | 12.90 |
9 | 0.03 | 0.017 | 1.67 |
GI50 is the concentration of the drug that causes 50% growth inhibition and values represent the average calculated across all 60 cell lines. Reported yields were calculated based on the recovery of the isolated compound from the two-step scale-up procedure.