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. 2020 Mar 30;15(4):1104–1114. doi: 10.1021/acschembio.0c00139

Table 1. NCI-60 Activity of the Active Principles of C17747 Haliclona chrysa Extract (2) and C15373 Hexabranchus sanguineus Extract (59)a.

compound GI50 (μM) yield of crude (%) yield of subfraction (%)
2 6.76 3.7 100
5 6.76 0.12 23.33
6 4.37 0.21 19.35
7 0.40 0.09 17.78
8 0.18 0.15 12.90
9 0.03 0.017 1.67
a

GI50 is the concentration of the drug that causes 50% growth inhibition and values represent the average calculated across all 60 cell lines. Reported yields were calculated based on the recovery of the isolated compound from the two-step scale-up procedure.