Table 2.
Targets identified for 16 phytochemicals.
| Target ID | Gene symbol | Target name | Distribution |
|---|---|---|---|
| T-1 | AKR1C2 | Aldo-keto reductase family 1 member C2 | Both |
| T-2 | ANG | Angiogenin | Licorice |
| T-3 | HMGCR | 3-Hydroxy-3-methylglutaryl-CoA reductase | Licorice |
| T-4 | VEGFA | Vascular endothelial growth factor A | Both |
| T-5 | HSD11B1 | Hydroxysteroid 11-beta dehydrogenase 1 | Licorice |
| T-6 | NUDT1 | Nudix hydrolase 1 | Licorice |
| T-7 | ABCB4 | ATP binding cassette subfamily B member 4 | White Peony |
| T-8 | ITGB2 | Integrin subunit beta 2 | Licorice |
| T-9 | TTR | Transthyretin | White Peony |
| T-10 | LGALS9 | Galectin 9 | White Peony |
| T-11 | ABCB1 | ATP binding cassette subfamily B member 1 | Both |
| T-12 | HMGB1 | High-mobility group box 1 | Licorice |
| T-13 | ABCC2 | ATP binding cassette subfamily C member 2 | Licorice |
| T-14 | CHEK1 | Checkpoint kinase 1 | White Peony |
| T-15 | ABCB11 | ATP binding cassette subfamily B member 11 | Both |
| T-16 | CD14 | CD14 molecule | White Peony |
| T-17 | LGALS1 | Galectin 1 | White Peony |
| T-18 | RORA | RAR-related orphan receptor A | White Peony |
| T-19 | SHBG | Sex hormone-binding globulin | Both |
| T-20 | LGALS3 | Galectin 3 | White Peony |
| T-21 | ESR1 | Estrogen receptor 1 | White Peony |
| T-22 | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Both |
| T-23 | PPARG | Peroxisome proliferator-activated receptor gamma | White Peony |
| T-24 | SERPINE1 | Serpin family E member 1 | White Peony |
| T-25 | IL2 | Interleukin 2 | White Peony |
| T-26 | PPARD | Peroxisome proliferator-activated receptor delta | White Peony |
| T-27 | NR1H2 | Nuclear receptor subfamily 1 group H member 2 | White Peony |
| T-28 | BMP2 | Bone morphogenetic protein 2 | Both |
| T-29 | MAPK8 | Mitogen-activated protein kinase 8 | White Peony |
| T-30 | GSTP1 | Glutathione S-transferase pi 1 | White Peony |
| T-31 | SRC | SRC protooncogene, nonreceptor tyrosine kinase | Licorice |
| T-32 | UGT2B7 | UDP glucuronosyltransferase family 2 member B7 | Licorice |
| T-33 | GJA1 | Gap junction protein alpha 1 | Licorice |
| T-34 | TLR2 | Toll-like receptor 2 | Licorice |
| T-35 | IL6 | Interleukin 6 | White Peony |
| T-36 | TLR4 | Toll-like receptor 4 | White Peony |
| T-37 | ABCC1 | ATP binding cassette subfamily C member 1 | Licorice |
| T-38 | PRKCD | Protein kinase C delta | White Peony |
| T-39 | CXCL8 | C-X-C motif chemokine ligand 8 | White Peony |
| T-40 | PRKCA | Protein kinase C alpha | White Peony |
| T-41 | ANXA1 | Annexin A1 | Licorice |
| T-42 | ATP1A1 | ATPase Na+/K+ transporting subunit alpha 1 | Both |
| T-43 | CYP3A4 | Cytochrome P450 family 3 subfamily A member 4 | Licorice |
| T-44 | CYP3A5 | Cytochrome P450 family 3 subfamily A member 5 | Licorice |
| T-45 | MAPK14 | Mitogen-activated protein kinase 14 | White Peony |
| T-46 | PTPN1 | Protein tyrosine phosphatase, nonreceptor type 1 | Both |
| T-47 | TREM1 | Triggering receptor expressed on myeloid cells 1 | White Peony |
| T-48 | PDPK1 | 3-Phosphoinositide-dependent protein kinase 1 | White Peony |
| T-49 | ALB | Albumin | Licorice |
| T-50 | FGF2 | Fibroblast growth factor 2 | Both |
| T-51 | TNF | Tumor necrosis factor | Both |
| T-52 | TNNI3 | Troponin I3, cardiac type | White Peony |
| T-53 | CYP1A1 | Cytochrome P450 family 1 subfamily A member 1 | Both |
| T-54 | TNNT2 | Troponin T2, cardiac type | White Peony |
| T-55 | MCL1 | BCL2 family apoptosis regulator | White Peony |
| T-56 | CFTR | Cystic fibrosis transmembrane conductance regulator | Licorice |
| T-57 | PPARGC1A | PPARG coactivator 1 alpha | Licorice |
| T-58 | BCL2 | BCL2, apoptosis regulator | Licorice |
| T-59 | F2 | Coagulation factor II, thrombin | White Peony |
| T-60 | CASP3 | Caspase 3 | Both |
| T-61 | MMP3 | Matrix metallopeptidase 3 | White Peony |
| T-62 | BCL2L1 | BCL2-like 1 | Licorice |
| T-63 | CYP2C19 | Cytochrome P450 family 2 subfamily C member 19 | Licorice |
| T-64 | F10 | Coagulation factor X | White Peony |
| T-65 | CYP2C9 | Cytochrome P450 family 2 subfamily C member 9 | Licorice |
| T-66 | CYP2C8 | Cytochrome P450 family 2 subfamily C member 8 | Licorice |
| T-67 | UGT1A1 | UDP glucuronosyltransferase family 1 member A1 | Licorice |
| T-68 | ICAM1 | Intercellular adhesion molecule 1 | Licorice |
| T-69 | GC | GC, vitamin D-binding protein | White Peony |
| T-70 | NR3C1 | Nuclear receptor subfamily 3 group C member 1 | Licorice |
| T-71 | LPL | Lipoprotein lipase | Licorice |
| T-72 | NFKB1 | Nuclear factor NF-kappa-B | Licorice |
| T-73 | TNNC1 | Troponin C, slow skeletal and cardiac muscles | White Peony |