Table 2.
Oxidative stress in the studied groups.
| Group I (N = 8) | Group II (N = 7) | Group III (N = 8) | Group IV (N = 8) | Group V (N = 8) | P value in group II (cisplatin) versus other groups |
P value in group V (combination) versus groups III, IV (monotherapy) |
|
|---|---|---|---|---|---|---|---|
| TNF-α(pg/ml) Mean ± SD |
29.45 ± 457 | 53.92 ± 0.477 | 47.22 ± 0.376 | 47.86 ± 0.162 | 46.02 ± 0.432 | 0.018∗ | NS |
|
| |||||||
| MDA content (nmol/g wet tissue) Mean ± SD |
407.21 ± 13.1 | 702.43 ± 33.21 | 551.5 ± 9.15 | 587.75 ± 13.4 | 433.25 ± 9.62 | 0.026∗ | 0.014∗ |
|
| |||||||
| GSH content (mmol/g wet tissue) Mean ± SD |
0.366 ± 0.0024 | 0.1726 ± 0.0059 | 0.2179 ± 0.0081 | 0.2011 ± 0.0072 | 0.2377 ± 0.0049 | 0.0167∗ | NS |
|
| |||||||
| SOD (U/g wet tissue) Mean ± SD |
7.57 ± 0.1077 | 4.16 ± 0.211 | 6.41 ± 0.1016 | 6.68 ± 0.055 | 6.18 ± 0.0529 | 0.009∗ | NS |
|
| |||||||
| CAT (U/g wet tissue) Mean ± SD |
0.595 ± 0.0041 | 0.4653 ± 0.0199 | 0.5244 ± 0.0063 | 0.5343 ± 0.0057 | 0.5728 ± 0.0079 | 0.011∗ | NS |
TNF: tumor necrosis factor. SOD: superoxide dismutase. MDA: malondialdehyde. GSH: glutathione content of renal tissue. CAT: catalase enzyme. ∗Significant. NS: nonsignificant.