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Interference Frequency Index (IFI) as a function of the compound pEC50 value for the 966 compounds that had sufficient potency to allow calculation of the EC50 values. Blue box indicates hits with IFI < 0.05. IFI measures the frequency that a compound is found to be a robust active in multiple HTS campaigns (i.e., the number of times a compound is found to be a robust active hit divided by the number of times it has been screened in HTS campaigns at GlaxoSmithKline).
