Skip to main content
. Author manuscript; available in PMC: 2020 Oct 11.
Published in final edited form as: ACS Infect Dis. 2019 Aug 14;5(10):1738–1753. doi: 10.1021/acsinfecdis.9b00168

Table 1. Potency distribution for the 4195 HTS primary actives that were progressed to dose-response experiments (Yeast HTS Growth Assay).

Potency ranges are given as negative log EC50 (i.e., pEC50) from four parameter logistic fits of 11-point dose-response curves.

pEC50 range # of Cmpds % of Cmpds
<4 3299 77%
4 < × < 4.99 741 18%
5 < × < 5.49 156 3.7%
5.5 < × < 5.99 53 1.3%
6 < × < 6.49 13 0.3%
6.5 < × < 6.59 2 0.05%