Table 2.

Effects of the crude extract (CE) of Jungia sellowii Less., its derived fractions (aqueous (AqF), butanol (BuOHF), ethyl acetate (EtOAcF)), and isolated compounds (curcuhidroquinone O-β-glucose (CUR) and piptizol (Pip), myeloperoxidase, adenosine deaminase activity, and nitrite/nitrate concentrations) in the inflammation induced by carrageenan in the mouse model of pleurisy.

Groups	Doses (mg/kg)	MPO (mU/mL) (% of inhibition)	ADA (U/L) (% of inhibition)	NOx (μM) (% of inhibition)
Sal	0.9%a	26.37 ± 0.81	1.51 ± 0.04	12.63 ± 1.35
Cg	1%a	165.30 ± 7.61	6.22 ± 0.22	91.46 ± 3.83
CE	50b	105.50 ± 4.85 (36.03 ± 2.94%)∗∗	2.98 ± 0.35 (52.09 ± 5.65%)∗∗	35.73 ± 1.93 (60.93 ± 2.11%)∗∗
AqF	25b	98.47 ± 4.84 (40.32 ± 2.93%)∗∗	1.87 ± 0.33 (69.91 ± 6.87%)∗∗	37.05 ± 6.84 (59.49 ± 7.48%)∗∗
EtOAcF	10b	88.95 ± 5.29 (46.09 ± 3, 20%)∗∗	1.89 ± 0.32 (69.59 ± 6.73%)∗∗	34.72 ± 2.32 (62.04 ± 3.28%)∗∗
BuOHF	10b	106.0 ± 6.65 (35.75 ± 5.21%)∗∗	2.65 ± 0.27 (57.52 ± 4.39%)∗∗	42.04 ± 1.88 (54.03 ± 2.06%)∗∗
CUR	2.5b	102.70 ± 5.99 (37.74 ± 3.63%)∗∗	4.23 ± 0.19 (45.1 ± 8.9%)∗∗	32.11 ± 2.22 (65.67 ± 2.96%)∗∗
Pip	1b	100.1 ± 3.79 (39.35 ± 2.30%)∗∗	3.07 ± 0.35 (29.5 ± 11.7%)∗∗	31.14 ± 5.66 (61.76 ± 5.87%)∗∗
Dex	0.5b	104.60 ± 3.22 (36.59 ± 1, 95%)∗∗	2.48 ± 0.15 (60.23 ± 3.10%)∗∗	15.04 ± 1.38 (83.56 ± 1.50%)∗∗

Crude extract (CE: 50 mg/kg) of Jungia sellowii Less., aqueous fraction (AqF 25 mg/kg), butanol fraction (BuOHF 10 mg/kg), ethyl acetate fraction (EtOAcF: 10 mg/kg), curcuhidroquinone O-β-glucose (CUR: 2.5 mg/kg), and piptizol (Pip: 1 mg/kg) administered 0.5 h before pleurisy induction by carrageenan (1%). Sal: animals treated only with sterile saline solution (NaCl, 0.9%); Cg: animals treated only with carrageenan (1%); Dex: animals pretreated with dexamethasone (0.5 mg/kg); ^aadministered by intrapleural injection (i.pl.); ^badministered by intraperitoneal route (i.p.). Each group represents the mean ± SEM of 5 animals compared to the positive control group (Cg); ANOVA/Newman-Keuls's test. ^∗p < 0.05; ^∗∗p < 0.01.