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Schematic of the EV-D68 genome. The EV-D68 genome contains the genome-linked protein VPg at the 5′ end, a 5′ untranslated region (UTR), a single open reading frame codes a polyprotein, a 3′ UTR, and the poly (A) tail. The polyprotein is cleaved into 11 individual viral proteins by two viral proteases, 2Apro and 3Cpro, during translation. Proteases and RNA-dependent RNA polymerase (RDRP) are indicated in the schematic.
