Table 3.

Estimates of the effect of covariates on 28- and 90-day mortality as evaluated in the eight Cox proportional hazards models

Variable	Mortality at 28 days				Mortality at 90 days
Model	Incident delirium	Days of delirium	Days of coma	Days of delirium or coma	Incident delirium	Days of delirium	Days of coma	Days of delirium or coma
Age	1.04 (1.03–1.06)	1.04 (1.03–1.06)	1.05 (1.03–1.06)	1.04 (1.03–1.05)	1.04 (1.03–1.05)	1.04 (1.03–1.05)	1.04 (1.03–1.05)	1.04 (1.03–1.05)
APACHE II score	1.07 (1.06–1.09)	1.07 (1.06–1.09)	1.07 (1.05–1.09)	1.07 (1.06–1.09)	1.07 (1.05–1.08)	1.07 (1.05–1.08)	1.06 (1.05–1.08)	1.06 (1.05–1.08)
Sepsis present	1.89 (1.46–2.43)	1.87 (1.45–2.42)	1.73 (1.33–2.24)	1.87 (1.45–2.42)	1.86 (1.48–2.33)	1.85 (1.47–2.33)	1.72 (1.36–2.17)	1.78 (1.41–2.25)
Mechanical ventilation use	2.81 (1.88–4.19)	2.77 (1.86–4.13)	2.24 (1.50–3.36)	2.49 (1.66–3.72)	2.16 (1.54–3.05)	2.14 (1.53–3.00)	1.83 (1.30–2.58)	1.95 (1.38–2.74)
ICU Length of Stay	0.97 (0.95–0.99)	0.97 (0.96–0.99)	0.92 (0.90–0.95)	0.95 (0.92–0.97)	1.00 (0.98–1.01)	1.00 (0.98–1.01)	0.97 (0.95–0.99)	0.98 (0.97–1.00)
Study Arm
Haloperidol 2 mg	1.08 (0.78–1.49)	1.06 (0.76–1.47)	1.20 (0.87–1.66)	1.29 (0.93–1.78)	1.17 (0.88–1.56)	1.18 (0.89–1.58)	1.31 (0.98–1.74)	0.97 (0.76–1.25)
Haloperidol 1 mg	1.18 (0.84–1.66)	1.16 (0.83–1.64)	1.12 (0.79–1.58)	1.21 (0.86–1.71)	1.15 (0.84–1.57)	1.15 (0.84–1.57)	1.16 (0.85–1.60)	0.99 (0.73–1.35)

Data is present as hazard ratios with their associated 95% confidence intervals