Fig. 4.

Intraplantar administration of the TAK1 inhibitor 5Z-7-oxozeaenol attenuated CCI-induced neuropathic pain and inhibited the upregulation of p-ERK, p-JNK, and p-p38 in the DRG and sciatic nerve. a, b The mechanical and thermal thresholds of CCI rats after intraplantar administration of OZ (10 μg/30 μL) on the operated side of CCI rats. Vehicle: 1% DMSO. n = 6 per group; #P < 0.05, ##P < 0.01, ###P < 0.001, compared with the l-CDL group; *P < 0.05, **P < 0.01, and ***P < 0.001, compared with 0 h. c-e The expression of p-ERK, p-JNK, and p-p38 in DRGs after intramuscular injection of the TAK1 inhibitor OZ (10 μg/30 μL). f-g The expression of p-ERK, p-JNK, and p-p38 in the sciatic nerve after intramuscular injection of the TAK1 inhibitor OZ (10 μg/30 μL). n = 4 per group; #P < 0.05, and ##P < 0.01, compared with the control group; *P < 0.05, and **P < 0.01, compared with the CCI group