Table 2. “Antisolvent Screening” to Determine Suitable Wash Solvent Mixture for Washing 1 to Prevent Nucleation of Particles from Mother Liquor and Reduce Paracetamol Dissolutiona.
| heptane | dodecane | isopropyl acetate | |
|---|---|---|---|
| ethanol | 50–50% (v/v) | 30–70% (v/v) | 30–70% (v/v) |
| isopropanol | 50–50% (v/v) | 60–40% (v/v) | 10–90% (v/v) |
| isoamyl alcohol | 20–80% (v/v) | 20–80% (v/v) | 0–100% (v/v) |
a
In bold is reported the percentage of pure crystallization solvent used to make the first wash solvent mixture.