Table 3. Isolation Strategy Selected for the Semicontinuous Run.
| suspension properties | range |
|---|---|
| mother liquor composition | saturated solution of paracetamol in ethanol, containing 2% mol/mol of acetanilide, and metacetamol |
| solid load (%, w/w) | 25 |
| slurry dose feed in port 1 (mL) | 65 |
| driving force filtration and washing (mbar) | 500 |
| wash solvent 1 | ethanol/n-heptane = 50:50 (% v/v) |
| wash solvent 2 | n-heptane |
| wash solvent 1 volume (corresponding to cake void volumes) | 0.44 |
| wash solvent 2 volume (corresponding to cake void volumes) | three washes of 0.44 void fractions |
| drying time (s) | 180 |
| drying gas temperature (°C) | room temperature (25 °C) |