Skip to main content
. 2020 Mar 26;24(4):520–539. doi: 10.1021/acs.oprd.9b00512

Table 3. Isolation Strategy Selected for the Semicontinuous Run.

suspension properties range
mother liquor composition saturated solution of paracetamol in ethanol, containing 2% mol/mol of acetanilide, and metacetamol
solid load (%, w/w) 25
slurry dose feed in port 1 (mL) 65
driving force filtration and washing (mbar) 500
wash solvent 1 ethanol/n-heptane = 50:50 (% v/v)
wash solvent 2 n-heptane
wash solvent 1 volume (corresponding to cake void volumes) 0.44
wash solvent 2 volume (corresponding to cake void volumes) three washes of 0.44 void fractions
drying time (s) 180
drying gas temperature (°C) room temperature (25 °C)